RESUMO
Aerosol transmission of pathogens can result in the rapid spread of disease. Introduction of a mobile air recirculation system based on high-efficiency particulate air filtration, photochemical oxidation, and germicidal ultraviolet light significantly decreased the bacterial load by over 40% under routine care in an emergency department. Application of this new technology promises to reduce the aerosol pathogen burden, thereby decreasing exposure risk and providing a safer environment for patient care.
Assuntos
Microbiologia do Ar , Bactérias/efeitos da radiação , Material Particulado/efeitos da radiação , Raios Ultravioleta , Ventilação , Movimentos do Ar , Poluição do Ar em Ambientes Fechados/análise , Humanos , Tamanho da PartículaRESUMO
[This corrects the article DOI: 10.1021/acsmedchemlett.7b00157.].
RESUMO
Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11, NVP-QAW039, fevipiprant), which exhibits improved potency on human eosinophils and Th2 cells, together with a longer receptor residence time, and is currently in clinical trials for severe asthma.
